Mütter können zu Allergie-Prävention beitragen

[Uli]

>>Gestillte Babys essen das Frühstücksei mit<<
So lautet die Überschrift im Allergo Journal 2205; 14
Um einer Hühnereiweißallergie entgegenzuwirken, wird stillenden Frauen eine Ei-freie Diät empfohlen. Eine randomisierte Studie untersuchte, ob Menge und Art des Eigehalts der Nahrung einen Einfluss auf den Eiproteingehalt in der Muttermilch hat.
Ja!
Fazit: Bei ¾ der untersuchten Frauen trat Ovalbumin nach Eigenuss dosisabhängig in die Muttermilch über. Ob es bei den restlichen Probandinnen zu einer verzögerten oder auch zu gar keiner Albuminexkretion in der Milch kam, bleibt offen.

2005
Effect of cooked and raw egg consumption on ovalbumin content of human milk: a randomized, double-blind, cross-over trial.

Palmer DJ, Gold MS, Makrides M.
Child Health Research Institute, Women's and Children's Hospital, North Adelaide, SA, Australia.
BACKGROUND: Maternal avoidance of egg intake has been recommended to treat egg allergy in breastfed infants.
OBJECTIVE: To determine if the concentration of ovalbumin (OVA) in human milk is directly related to the quantity and form of egg consumed by breastfeeding mothers. METHODS: Randomized, blinded, cross-over, intervention trial. Breastfeeding women (n = 41) attended four clinic days between 11 and 14 weeks of lactation and on each day were randomly allocated to receive a test breakfast, identical except for the egg content (no egg, one raw egg, half a cooked egg or one cooked egg). Breast milk samples were collected at two hourly intervals for 8 h and their OVA concentration measured by ELISA. RESULTS: There was a direct, dose-response between the amount of cooked egg ingested and the peak OVA concentration (no egg 0.05 ng/mL [95% confidence interval (CI), 0.01-0.11], half a cooked egg 2.24 ng/mL [95% CI, 0.57-3.91], one cooked egg 3.16 ng/mL [95% CI, 1.41-4.91], n = 41, P<0.05) as well as the total OVA excretion (no egg 0.18 ng/mL/h [95% CI, 0.04-0.39], half a cooked egg 4.93 ng/mL/h [95% CI, 1.40-8.46], one cooked egg 9.14 ng/mL/h [95% CI, 4.25-14.03], n = 41, P<0.05). The peak concentration and total OVA excretion in response to one raw egg did not differ from ingesting half a cooked egg. There was no detectable OVA in the breast milk of 24% (10/41) women up to 8 h after any egg challenge.
CONCLUSION: OVA was detected in the breast milk of lactating women up to 8 h after a controlled intake of egg. A dose-response correlation was indicated. As excretion of OVA in human milk appears to be a normal phenomenon, further studies need to determine the threshold of OVA excretion that leads to symptoms in egg-allergic breastfed infants.
http://www.ncbi.nlm.nih.gov/entrez/query...t=Abstract

Und vor nun fast schon vor 10 Jahren wurde das Gleiche mit Kuhmilch versucht ( in Japan!)
Hier wurde bei 62,5% der Probandinnen Beta-Lactoglobulin in der Muttermilch nachgewiesen, aber nur bei 8,3% Ovalbumin.
Wie es scheint, kann mehr Beta-Lactoglobulin nachgewiesen werden, je länger die Probandin ( Mutter) Milch konsumiert (hat).

Leider scheint es keine weiteren „Studien“ zu dieser Thematik / Problematik zu geben.......

: Am J Clin Nutr. 1997 Jan;65(1):30-5
Consumption of cow milk and egg by lactating women and the presence of beta-lactoglobulin and ovalbumin in breast milk.
· Fukushima Y,
· Kawata Y,
· Onda T,
· Kitagawa M.
Nestle Japan Ltd., Scientific Liaison Office, Tokyo, KGE02664@iftyserve.ur.jp.

beta-Lactoglobulin and ovalbumin in mature human milk in healthy lactating Japanese women (n = 24) were determined by using an enzyme-linked immunosorbent assay. Subjects consumed > or = +200 mL cow milk/d for 1 wk before the sampling day and exactly 200 mL cow milk on the morning of the sampling day. beta-Lactoglobulin was detected (> 0.1 microgram/L) in breast milk in 15 of the 24 subjects (62.5%), with a maximum concentration of 16.5 micrograms/L. Ovalbumin was detected in only two subjects (8.3%) after the subjects followed their usual diet. beta-Lactoglobulin concentrations were low in the subjects whose cow milk consumption during the entire lactating period was low, even though all subjects consumed the same amount of cow milk before sampling. This result suggests that beta-lactoglobulin concentrations in breast milk are related to long-term consumption of cow milk. Amounts of food antigens in breast milk may be controlled by modifying the daily maternal diet.
PMID: 8988909 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query...med_docsum

Uli