14.08.2005, 10:20
J Fam Pract. 2005 Jul;54(7):613-20.
Do probiotics reduce adult lactose intolerance? A systematic review.
Levri KM, Ketvertis K, Deramo M, Merenstein JH, D'Amico F.
University of Pittsburgh Medical Center/St. Margaret, 3937 Butler Street, Pittsburgh, PA 15201, USA. kl55882@aol.com
PURPOSE: To assess the efficacy of oral probiotics in adults with lactose intolerance through a systematic review of its effects on symptoms and breath hydrogen tests, and whether adding probiotics to nonfermented dairy products decreases lactose intolerance at that meal.
METHODS: We searched randomised controlled trials published between 1966 and December 2002. Databases in the search strategy included Medline and AMED. We reviewed references of clinical trials and contacted authors of major articles and manufacturers of probiotic commercial products. Quality assessment was based on the McMaster guides and was performed by 5 independent eviewers. Data extraction was performed by 2 reviewers.
RESULTS: A master list of 90 articles was compiled. Ten articles met inclusion and exclusion criteria and were consistent with our clinical question. Of the 9 studies that measured breath hydrogen, 3 were positive, 3 were negative, and 3 had both positive and negative results. Of the 7 studies that measured symptoms, 1 yielded positive results, 5 were negative, and 1 had both positive and negative outcomes.
CONCLUSIONS: Probiotic supplementation in general did not alleviate the symptoms and signs of lactose intolerance in adults in this review. Some evidence suggests that specific strains, concentrations, and preparations are effective. Further clinical trials of specific strains and concentrations are necessary to delineate this potential therapeutic relationship.
http://www.findarticles.com/p/articles/m..._n14796557
Hier wurden nachträglich Studien bewertet, die zwischen 1966 und 2002 die Vorteile oral verabreichter Probiotika bei erwachsenen Laktose-Intoleranten aufzeigen sollten. Die Effektivität wurde anhand eines H2-Atemtests und/oder der Symptomatik überprüft.
Es waren 90 Publikationen zu diesem Thema zusammengetragen worden, bei 10 Publikationen trafen die Auswahlkriterien der o.g. Autoren zu.
- bei 9 der Studien, die per H2-Atemtest die Auswirkungen der Probiotika überprüft hatten, zeigten 3 positive, 3 negative und 3 beides: positive wie negative Ergebnisse.
- von 7 Studien, die sich auf die Symptome bezogen hatten, zeigte eine Studie positive Auswirkungen, 5 negative- und 1 beides: positive wie negative Auswirkungen.
Fazit: Die Gabe von Probiotika vermindert im Allgemeinen nicht die Symptome eines erwachsenen Laktoseintoleranten . Zukünftige Studien über bestimmte Zusammensetzung der Präparate sollten durchgeführt werden, um einen therapeutischen Nutzen klarzulegen.
Auf „gut Deutsch“ : Nix Genaues weiß man nicht – kann man nicht sagen..........
Uli
Do probiotics reduce adult lactose intolerance? A systematic review.
Levri KM, Ketvertis K, Deramo M, Merenstein JH, D'Amico F.
University of Pittsburgh Medical Center/St. Margaret, 3937 Butler Street, Pittsburgh, PA 15201, USA. kl55882@aol.com
PURPOSE: To assess the efficacy of oral probiotics in adults with lactose intolerance through a systematic review of its effects on symptoms and breath hydrogen tests, and whether adding probiotics to nonfermented dairy products decreases lactose intolerance at that meal.
METHODS: We searched randomised controlled trials published between 1966 and December 2002. Databases in the search strategy included Medline and AMED. We reviewed references of clinical trials and contacted authors of major articles and manufacturers of probiotic commercial products. Quality assessment was based on the McMaster guides and was performed by 5 independent eviewers. Data extraction was performed by 2 reviewers.
RESULTS: A master list of 90 articles was compiled. Ten articles met inclusion and exclusion criteria and were consistent with our clinical question. Of the 9 studies that measured breath hydrogen, 3 were positive, 3 were negative, and 3 had both positive and negative results. Of the 7 studies that measured symptoms, 1 yielded positive results, 5 were negative, and 1 had both positive and negative outcomes.
CONCLUSIONS: Probiotic supplementation in general did not alleviate the symptoms and signs of lactose intolerance in adults in this review. Some evidence suggests that specific strains, concentrations, and preparations are effective. Further clinical trials of specific strains and concentrations are necessary to delineate this potential therapeutic relationship.
http://www.findarticles.com/p/articles/m..._n14796557
Hier wurden nachträglich Studien bewertet, die zwischen 1966 und 2002 die Vorteile oral verabreichter Probiotika bei erwachsenen Laktose-Intoleranten aufzeigen sollten. Die Effektivität wurde anhand eines H2-Atemtests und/oder der Symptomatik überprüft.
Es waren 90 Publikationen zu diesem Thema zusammengetragen worden, bei 10 Publikationen trafen die Auswahlkriterien der o.g. Autoren zu.
- bei 9 der Studien, die per H2-Atemtest die Auswirkungen der Probiotika überprüft hatten, zeigten 3 positive, 3 negative und 3 beides: positive wie negative Ergebnisse.
- von 7 Studien, die sich auf die Symptome bezogen hatten, zeigte eine Studie positive Auswirkungen, 5 negative- und 1 beides: positive wie negative Auswirkungen.
Fazit: Die Gabe von Probiotika vermindert im Allgemeinen nicht die Symptome eines erwachsenen Laktoseintoleranten . Zukünftige Studien über bestimmte Zusammensetzung der Präparate sollten durchgeführt werden, um einen therapeutischen Nutzen klarzulegen.
Auf „gut Deutsch“ : Nix Genaues weiß man nicht – kann man nicht sagen..........
Uli