22.08.2005, 10:18
Am J Clin Nutr. 1999 May;69(5):973-9.
Fructooligosaccharides and lactulose cause more symptoms in lactose maldigesters and subjects with pseudohypolactasia than in control lactose digesters.
Teuri U, Vapaatalo H, Korpela R.
Department of Applied Chemistry and Microbiology, University of Helsinki, Finland.
BACKGROUND: Many lactose maldigesters tolerate more lactose in experimental studies than in everyday life, in which their symptoms may result from other carbohydrates as well. OBJECTIVE: The question of whether the symptoms caused by large quantities of carbohydrates are more severe in lactose maldigesters than in control lactose digesters or in lactose digesters who report milk to be the cause of their gastrointestinal symptoms (pseudohypolactasic subjects) was studied in a randomized, double-blind, crossover study. Comparisons between commonly used diagnostic methods for lactose maldigestion were also made. DESIGN: The subjects were 40 women aged 20-63 y from 3 groups: lactose maldigesters (n = 12), pseudohypolactasic subjects (n = 15), and control lactose digesters (n = 13). The subjects were given either 50 g lactose, 50 g sucrose, 25 g lactulose, or 25 g fructooligosaccharides. After carbohydrate ingestion, urine was collected and the breath-hydrogen concentration was measured every 30 min for 3 h. Blood glucose was measured every 20 min for 1 h and subjective gastrointestinal symptoms were monitored for 8 h with a questionnaire. RESULTS: When lactulose and fructooligosaccharides were ingested, the lactose maldigesters (P = 0.04 and 0.09, respectively) and the pseudohypolactasic subjects (P = 0.006 and 0.01, respectively) reported more symptoms than did the control lactose digesters. Sucrose caused more symptoms in the lactose maldigesters than in the control lactose digesters (P = 0.05).
CONCLUSIONS: Lactose maldigesters and lactose digesters with pseudohypolactasia experience more symptoms than control lactose digesters after a single intake of large amounts of indigestible carbohydrates. Lactose maldigesters also experience more symptoms after ingesting sucrose.
PMID: 10232639 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query...query_hl=2
Ballaststoffe ( Fructooligosaccharide / FOS) und Lactulose verursachen mehr Symptome bei Laktose –intoleranten Patienten als bei Kontrollen, die Laktose vertragen.
( wenn ich nur wüsste, was „Pseudohypolaktasier“ sein sollen : entweder man – bzw. der Darm – produziert noch Laktose oder nicht ; „pseudo“ bedeutet ja, er tut nur so als ob........ ?( ?( ?( ????)
In dieser Studie wurden LI`ler und „ Pseudo-LI`ler“ getestet, inwieweit sie Ballaststoffe, Laktulose oder gar Saccharose vertragen würden, denn:
>>....viele LI`ler würden bei Tests mehr Laktose tolerieren als im Alltag!<< und da wollte man herausfinden, ob nicht auch noch andere Kohlenhydrate für Reaktionen/Symptome verantwortlich zu machen seien!
Man provozierte die Pat. also mit 50 g Laktose, 50 g Saccharose, 25 g Laktulose und 25 g FOS : die LI`ler und „Pseudo-LI`ler“ reagierten mit vermehrten Beschwerden!!
Nach diesen Erkenntnissen sei nun die Frage erlaubt, weshalb in den meisten der Medikamente, die LI`lern so gerne verordnet/empfohlen werden, FOS zu finden sind??????? X( X( X(
Uli
Mehr zu Ballaststoffen:http://www.lebensmittelallergie.info/thr...id=11&sid=
Fructooligosaccharides and lactulose cause more symptoms in lactose maldigesters and subjects with pseudohypolactasia than in control lactose digesters.
Teuri U, Vapaatalo H, Korpela R.
Department of Applied Chemistry and Microbiology, University of Helsinki, Finland.
BACKGROUND: Many lactose maldigesters tolerate more lactose in experimental studies than in everyday life, in which their symptoms may result from other carbohydrates as well. OBJECTIVE: The question of whether the symptoms caused by large quantities of carbohydrates are more severe in lactose maldigesters than in control lactose digesters or in lactose digesters who report milk to be the cause of their gastrointestinal symptoms (pseudohypolactasic subjects) was studied in a randomized, double-blind, crossover study. Comparisons between commonly used diagnostic methods for lactose maldigestion were also made. DESIGN: The subjects were 40 women aged 20-63 y from 3 groups: lactose maldigesters (n = 12), pseudohypolactasic subjects (n = 15), and control lactose digesters (n = 13). The subjects were given either 50 g lactose, 50 g sucrose, 25 g lactulose, or 25 g fructooligosaccharides. After carbohydrate ingestion, urine was collected and the breath-hydrogen concentration was measured every 30 min for 3 h. Blood glucose was measured every 20 min for 1 h and subjective gastrointestinal symptoms were monitored for 8 h with a questionnaire. RESULTS: When lactulose and fructooligosaccharides were ingested, the lactose maldigesters (P = 0.04 and 0.09, respectively) and the pseudohypolactasic subjects (P = 0.006 and 0.01, respectively) reported more symptoms than did the control lactose digesters. Sucrose caused more symptoms in the lactose maldigesters than in the control lactose digesters (P = 0.05).
CONCLUSIONS: Lactose maldigesters and lactose digesters with pseudohypolactasia experience more symptoms than control lactose digesters after a single intake of large amounts of indigestible carbohydrates. Lactose maldigesters also experience more symptoms after ingesting sucrose.
PMID: 10232639 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query...query_hl=2
Ballaststoffe ( Fructooligosaccharide / FOS) und Lactulose verursachen mehr Symptome bei Laktose –intoleranten Patienten als bei Kontrollen, die Laktose vertragen.
( wenn ich nur wüsste, was „Pseudohypolaktasier“ sein sollen : entweder man – bzw. der Darm – produziert noch Laktose oder nicht ; „pseudo“ bedeutet ja, er tut nur so als ob........ ?( ?( ?( ????)
In dieser Studie wurden LI`ler und „ Pseudo-LI`ler“ getestet, inwieweit sie Ballaststoffe, Laktulose oder gar Saccharose vertragen würden, denn:
>>....viele LI`ler würden bei Tests mehr Laktose tolerieren als im Alltag!<< und da wollte man herausfinden, ob nicht auch noch andere Kohlenhydrate für Reaktionen/Symptome verantwortlich zu machen seien!
Man provozierte die Pat. also mit 50 g Laktose, 50 g Saccharose, 25 g Laktulose und 25 g FOS : die LI`ler und „Pseudo-LI`ler“ reagierten mit vermehrten Beschwerden!!
Nach diesen Erkenntnissen sei nun die Frage erlaubt, weshalb in den meisten der Medikamente, die LI`lern so gerne verordnet/empfohlen werden, FOS zu finden sind??????? X( X( X(
Uli
Mehr zu Ballaststoffen:http://www.lebensmittelallergie.info/thr...id=11&sid=