Hemmung der Magensäureproduktion kann Nahrungsmittelallergien auslösen

[Uli]

Hier noch ein weiterer Nebeneffekt : Nahrungsmittelallergiker reagieren um so massiver auf bekannte Allergene, je höher der Säuregehalt des Magens ist.
Soll heißen: die Magensäure ist hauptverantwortlich für die "Entschärfung" von Nahrungsproteinen.

Fazit ( Allergo Journal 2008/ 17, Seite 17 )

Ist der Magen-pH-Wert erhöht, werden Fischproteine ( um die ging es in diesem Beitrag) deutlich weniger abgebaut. Damit sinkt die zur Auslösung der allergischen Reaktion notwenidige Allergenmenge.
Nahrungsmittelallergiker sollten daher bei der Einnahme von Medikamenten zur Erhöhung des Magen-pH- Wertes vorsichtig sein.

The effect of gastric digestion on food allergy.
PURPOSE

OF REVIEW:
The role of the stomach as the primary location of protein digestion is very well recognized, leading to classification of proteins as digestion-resistant or digestion-labile. This review analyses the role of gastric digestion in food allergy.

RECENT FINDINGS:
Hindrance of gastric digestion by elevation of the gastric pH, the therapeutic goal of anti-ulcer medication, was recently shown to trigger food allergy via oral sensitization in a murine food allergy model. The relevance in humans was assessed in an observational study of 152 gastroenterological patients who were medicated with anti-ulcer drugs due to dyspeptic disorders. Twenty-five percent of all patients developed a boost or de-novo IgE formation towards regular constituents of the daily diet. The clinical relevance of the induced antibodies was confirmed by positive skin and oral-provocation tests. Moreover, the importance of gastric digestion was also proven for food-allergic patients, as the allergenicity of allergens were reduced up to a 10,000-fold by gastric digestion.

SUMMARY:
These recent studies indicate for the first time the important gate-keeping function of gastric digestion, both in the sensitization and the effector phases of food allergy.

http://www.find-health-articles.com/rec_...llergy.htm

Uli